Application of In Situ Raman Spectroscopy To Facilitate Use of Hydrogen Peroxide on Kilogram Scale

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• 作者：Dawn Cohen ; Andrew Cosbie ; Robert R. Milburn ; Stephen Shaw ; Yong Xie
• 刊名：Organic Process Research & Development
• 出版年：2014
• 出版时间：December 19, 2014
• 年：2014
• 卷：18
• 期：12
• 页码：1807-1811
• 全文大小：324K
• ISSN：1520-586X

文摘

The safe implementation of a hydrogen-peroxide-mediated oxidation of a poorly reactive sulfide to the corresponding sulfone is described. A three-tiered approach incorporating process understanding, safety studies, and real time PAT (in situ Raman spectroscopy) was leveraged to ensure safe operation. Further investigation of an in situ Raman spectroscopy model for the reaction and its use for in-process control and end-point determination is discussed.