文摘
Bergenin (<b>1b>) is a C-glucoside of 4-O-methylgallic acid with known antiarthritic activity attributed to modulation of cytokine production. The present study was undertaken to evaluate whether <b>1b> has antinociceptive properties in models of inflammatory pain and to investigate its possible mechanisms of action. Pretreatment with <b>1b> (12.5鈥?00 mg/kg, ip) produced a dose-related inhibition of acetic acid-induced writhing in mice. Furthermore, treatment with <b>1b> (50 and 100 mg/kg) inhibited both the early and late phases in a formalin test. In addition, <b>1b> (50 and 100 mg/kg, ip) inhibited mechanical hyperalgesia, edema, and paw production of hyperalgesic cytokines (TNF-伪 and IL-1尾) induced by complete Freund鈥檚 adjuvant. However, the local production of IL-10, an anti-inflammatory cytokine, was not altered by <b>1b> (100 mg/kg, ip). Treatment with <b>1b> produced a similar profile of antinociception in wild-type and IL-10-deficient mice. Mice treated with <b>1b> did not show any motor performance alterations or apparent systemic toxicity. The results presented herein demonstrate that bergenin has consistent antinociceptive and anti-inflammatory properties, acting by the inhibition of IL-1尾 and TNF-伪 production, and suggest its potential for the control of inflammatory pain.