Alternate “Drug” Delivery Utilizing β-Lactam Cores: Syntheses and Biological Evaluation of β-Lactams Bearing Isocyanate Precursors
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- 作者：Mark W. Majewski ; Patricia A. Miller ; Allen G. Oliver ; Marvin J. Miller
- 刊名：Journal of Organic Chemistry
- 出版年：2017
- 出版时间：January 6, 2017
- 年：2017
- 卷：82
- 期：1
- 页码：737-744
- 全文大小：406K
- ISSN：1520-6904
文摘
The synthesis of a small set of β-lactams containing isocyanate precursors is described. The release of the isocyanate precursor in model hydrolysis experiments was substantiated by trapping experiments, thus confirming that β-lactams can be designed that are capable of releasing alternatively reactive species. Preliminary biological assessments are also briefly discussed.