Enantioselective Mukaiyama–Michael Reaction of Cyclic α-Alkylidene β-Keto Phosphine Oxide and Phosphonate and Asymmetric Synthesis of (R)-Homosarkomycin
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- 作者：Kotaro Nagatani ; Atsushi Minami ; Haruka Tezuka ; Yunosuke Hoshino ; Masahisa Nakada
- 刊名：Organic Letters
- 出版年：2017
- 出版时间：February 17, 2017
- 年：2017
- 卷：19
- 期：4
- 页码：810-813
- 全文大小：355K
- ISSN：1523-7052
文摘
The asymmetric Mukaiyama–Michael reaction of cyclic α-alkylidene β-oxo phosphates and phosphine oxides that proceeds in a highly enantioselective manner is described. It is possible to carry out these reactions using a catalytic amount of a bisoxazoline–Cu(II) complex without decreasing the enantioselectivity, and one of the products has been successfully used for the first enantioselective synthesis of (R)-homosarkomycin.