Hirsutalins A−H, Eunicellin-Based Diterpenoids from the Soft Coral Cladiella hirsuta

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• 作者：Bo-Wei Chen ; Shu-Ming Chang ; Chiung-Yao Huang ; Chih-Hua Chao ; Jui-Hsin Su ; Zhi-Hong Wen ; Chi-Hsin Hsu ; Chang-Feng Dai ; Yang-Chang Wu ; Jyh-Horng Sheu
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：November 29, 2010
• 年：2010
• 卷：73
• 期：11
• 页码：1785-1791
• 全文大小：263K
• 年卷期：v.73,no.11(November 29, 2010)
• ISSN：1520-6025

文摘

Eight new eunicellin-base diterpenoids, hirsutalins A−H (1−8), were isolated from the soft coral Cladiella hirsuta. Their structures were elucidated by spectroscopic methods, particularly in 1D and 2D NMR experiments. The absolute configuration of 1 was determined by Mosher’s method. Compounds 1, 5, and 6 have been shown to exhibit cytotoxicity toward several cancer cell lines. Compounds 2−4 and 8 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein, with compound 2 also effectively reducing the level of COX-2 protein.