Eunicellin-Based Diterpenoids from the Formosan Soft Coral Klyxum molle with Inhibitory Activity on Superoxide Generation and Elastase Release by Neutrophils

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• 作者：Ming-Chang Lin ; Bo-Wei Chen ; Chiung-Yao Huang ; Chang-Feng Dai ; Tsong-Long Hwang ; Jyh-Horng Sheu
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：September 27, 2013
• 年：2013
• 卷：76
• 期：9
• 页码：1661-1667
• 全文大小：294K
• 年卷期：v.76,no.9(September 27, 2013)
• ISSN：1520-6025

文摘

Eleven new eunicellin-based diterpenoids possessing a cladiellane skeleton with a C-2, C-9 ether bridge, klymollins I鈥揝 (1鈥?b>11), have been isolated from the EtOAc extract of the soft coral Klyxum molle from Taiwan waters. The structures of compounds 1鈥?b>11 were elucidated by extensive spectroscopic analysis, including 2D NMR spectroscopy (COSY, HSQC, HMBC, and NOESY). Compound 5 exhibited cytotoxicity toward several cancer cell lines. Compound 5 is the first eunicellin-based metabolite bearing a phenyl group and displays significant inhibition of both superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced human neutrophils.