Catalytic Asymmetric Vinylogous Mannich-type (AVM) Reaction of Nonactivated 伪-Angelica Lactone
详细信息 查看全文
- 作者：Lin Zhou ; Lili Lin ; Jie Ji ; Mingsheng Xie ; Xiaohua Liu ; Xiaoming Feng
- 刊名：Organic Letters
- 出版年：2011
- 出版时间：June 17, 2011
- 年：2011
- 卷：13
- 期：12
- 页码：3056-3059
- 全文大小：757K
- 年卷期：v.13,no.12(June 17, 2011)
- ISSN：1523-7052
文摘
A direct highly diastereo- and enantioselective asymmetric vinylogous Mannich-type (AVM) reaction of aldimines with nonactivated natural 伪-angelica lactone has been successfully developed. It was demonstrated that the nonactivated natural 伪-angelica lactone is a useful vinylogous nucleophile to give the chiral 未-amino 纬,纬-disubstituted butenolide carbonyl derivatives. The N,N鈥?/i>-dioxide L2鈥揝cIII complex is efficient toward the obtention of a range of corresponding products with adjacent quaternary and tertiary stereocenters in excellent dr and ee values.