Asperelines A−F, Peptaibols from the Marine-Derived Fungus Trichoderma asperellum

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• 作者：Jinwei Ren ; Chunmei Xue ; Li Tian ; Minjuan Xu ; Jian Chen ; Zhiwei Deng ; Peter Proksch ; Wenhan Lin
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：June 26, 2009
• 年：2009
• 卷：72
• 期：6
• 页码：1036-1044
• 全文大小：409K
• 年卷期：v.72,no.6(June 26, 2009)
• ISSN：1520-6025

文摘

Fermentation of the marine-derived fungus Trichoderma asperellum, collected from the sediment of the Antarctic Penguin Island, resulted in the isolation of six new peptaibols named asperelines A−F (1−6), which are characterized by an acetylated N-terminus and a C-terminus containing an uncommon prolinol residue. Structures were determined by extensive 1D and 2D NMR (¹H−¹H COSY, HMQC, HMBC, NOESY) spectroscopic data analysis combined with ESIMS/MS fragmentation. The absolute configurations of the amino acid residues possessing a chiral α-carbon and of the prolinol residue were determined to be l and S, respectively, using a new method of ¹H NMR spectroscopic comparison of complexes formed between the chiral reagent Ru(d₄-Por*)CO and amino acids derived from the peptaibols with those formed with reference standards.