Asymmetric Allylic Alkylation in Combination with Ring-Closing Metathesis for the Preparation of Chiral N-Heterocycles

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• 作者：Johannes F. Teichert ; Suyan Zhang ; Anthoni W. van Zijl ; Jan Willem Slaa ; Adriaan J. Minnaard ; Ben L. Feringa
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：October 15, 2010
• 年：2010
• 卷：12
• 期：20
• 页码：4658-4660
• 全文大小：158K
• 年卷期：v.12,no.20(October 15, 2010)
• ISSN：1523-7052

文摘

Asymmetric copper-catalyzed allylic substitution with methylmagnesium bromide is employed in combination with ring-closing olefin metathesis or ene−yne metathesis to achieve the synthesis of chiral, unsaturated nitrogen heterocycles. The resulting six- to eight-membered chiral heterocycles are accessible in high yields and with excellent enantioselectivities.