文摘
An efficient catalytic asymmetric synthesis of chiral 纬-butenolides was developed based on the hetero-allylic asymmetric alkylation (h-AAA) in combination with ring closing metathesis (RCM). The synthetic potential of the h-AAA-RCM protocol was illustrated with the facile synthesis of (鈭?-whiskey lactone, (鈭?-cognac lactone, (鈭?-nephrosteranic acid, and (鈭?-roccellaric acid.