Collective Activation of MRI Agents via Encapsulation and Disease-Triggered Release
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- 作者：Mathieu L. Viger ; Jagadis Sankaranarayanan ; Caroline de Gracia Lux ; Minnie Chan ; Adah Almutairi
- 刊名：The Journal of the American Chemical Society
- 出版年：2013
- 出版时间：May 29, 2013
- 年：2013
- 卷：135
- 期：21
- 页码：7847-7850
- 全文大小：227K
- 年卷期：v.135,no.21(May 29, 2013)
- ISSN：1520-5126
文摘
An activation mechanism based on encapsulated ultrasmall gadolinium oxide nanoparticles (Gd oxide NPs) in bioresponsive polymer capsules capable of triggered release in response to chemical markers of disease (i.e., acidic pH, H2O2) is presented. Inside the hydrophobic polymeric matrices, the Gd oxide NPs are shielded from the aqueous environment, silencing their ability to enhance water proton relaxation. Upon disassembly of the polymeric particles, activation of multiple contrast agents generates a strong positive contrast enhancement of >1 order of magnitude.