Toward an Artificial Aldolase

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• 作者：Daniel Font ; Sonia Sayalero ; Amaia Bastero ; Ciril Jimeno ; Miquel A. Peric&agrave ; s
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：January 17, 2008
• 年：2008
• 卷：10
• 期：2
• 页码：337 - 340
• 全文大小：169K
• 年卷期：v.10,no.2(January 17, 2008)
• ISSN：1523-7052

文摘

A new functional polymer where proline is bonded to polystyrene through a 1,2,3-triazole linker depicts characteristics targeted for an artificialaldolase. In spite of the hydrophobicity of the polymer backbone, the resin swells in water with building of an aqueous microenvironment.This property, arising from the formation of a hydrogen-bond network connecting the proline and 1,2,3-triazole fragments, is translated intoa very high catalytic activity and enantioselectivity toward direct aldol reactions in water.