Kahalalide Derivatives from the Indian Sacoglossan Mollusk Elysia grandifolia

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• 作者：Mohamed Ashour ; RuAngelie Edrada ; Rainer Ebel ; Victor Wray ; Wim Wä ; tjen ; K. Padmakumar ; Werner E. G. Mü ; ller ; Wen Han Lin ; Peter Proksch
• 刊名：Journal of Natural Products
• 出版年：2006
• 出版时间：November 2006
• 年：2006
• 卷：69
• 期：11
• 页码：1547 - 1553
• 全文大小：112K
• 年卷期：v.69,no.11(November 2006)
• ISSN：1520-6025

文摘

Two new cyclic depsipeptide derivatives, kahalalides R (1) and S (2), together with two known congeners, kahalalidesF (3) and D (4), were isolated from the Indian sacoglossan mollusk Elysia grandifolia. The structures of the newcompounds were unambiguously established on the basis of NMR spectroscopic (¹H, ¹³C, COSY, HMBC) and massspectrometric (FABMS, ESIMS, MALDI-TOF/PSD) data, which also included Marfey amino acid analyses. The newderivative kahalalide R was found to exert comparable or even higher cytotoxicity than the potential drug candidatekahalalide F toward the MCF7 human mammary carcinoma cell line.