Confinement of Nucleic Acid Bases and Related Compounds Using Tetra-p-sulfonatocalix[4]arene

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• 作者：Peter J. Nichols ; Mohamed Makha ; and Colin L. Raston
• 刊名：Crystal Growth & Design
• 出版年：2006
• 出版时间：May 2006
• 年：2006
• 卷：6
• 期：5
• 页码：1161 - 1167
• 全文大小：626K
• 年卷期：v.6,no.5(May 2006)
• ISSN：1528-7505

文摘

Supramolecular complexes of tetra-p-sulfonatocalix[4]arene and guanine, cytosine, benzimidazole, and 2-hydroxybenzimidazole have been isolated in the solid state, and their structures have been elucidated using single-crystal X-ray diffractiondata, as have 2-hydroxybenzimidazole complexes and complexes with large cations tetraphenylphosphonium (Ph₄P⁺) andtriethylbenzylammonium (Et₃BzN⁺). These large cations disrupt the usual bilayer arrangement of the sulfonated calixarenes, as canbenzimadole itself, and a combination of guanine and cytosine, in the absence of the large cations. Some of the structures show a"molecular capsule" type arrangement with two calixarenes arranged with their cavities directed toward each other, effectivelyshrouding two nucleic acid bases.