Lanostane-Type Triterpenes from the Mushroom Astraeus pteridis with Antituberculosis Activity
详细信息 查看全文
- 作者：Rita Stanikunaite ; Mohamed M. Radwan ; James M. Trappe ; Frank Fronczek ; Samir A. Ross
- 刊名：Journal of Natural Products
- 出版年：2008
- 出版时间：December 26, 2008
- 年：2008
- 卷：71
- 期：12
- 页码：2077-2079
- 全文大小：131K
- 年卷期：v.71,no.12(December 26, 2008)
- ISSN：1520-6025
文摘
Bioassay-guided fractionation of an EtOH extract of the truffle-mimiking mushroom Astraeus pteridis led to the isolation and identification of three new (3−5) and two known (1, 2) lanostane triterpenes and phenylalanine betaine (6). The structures of the isolates were elucidated on the basis of 1D and 2D NMR spectroscopic data, HRESIMS results, and X-ray crystallographic analysis. Compounds 5 and 1 showed moderate activity against Mycobacterium tuberculosis with MIC values of 34.0 and 58.0 μg/mL, respectively.