Sorocenols G and H, Anti-MRSA Oxygen Heterocyclic Diels−Alder-Type Adducts from Sorocea muriculata Roots

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• 作者：Samir A. Ross ; Raquel Rodrí ; guez-Guzmá ; n ; Mohamed M. Radwan ; Melissa Jacob ; Yuanqing Ding ; Xing-Cong Li ; Daneel Ferreira ; Susan P. Manly
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：October 24, 2008
• 年：2008
• 卷：71
• 期：10
• 页码：1764-1767
• 全文大小：128K
• 年卷期：v.71,no.10(October 24, 2008)
• ISSN：1520-6025

文摘

Bioassay-guided fractionation of a root extract of Sorocea muriculata led to the isolation and identification of two new oxygen heterocyclic Diels−Alder-type adducts, sorocenols G (1) and H (2), along with lupeol-3-(3′R-hydroxytetradecanoate) and oxyresveratrol. The structures of 1 and 2 were elucidated using 1D and 2D NMR spectroscopic and HRMS data and by comparison with reported values. The absolute configurations of 1 and 2 were established by analysis of their experimental and theoretically calculated CD spectra. Compounds 1 and 2 showed significant and selective activity against methicillin-resistant Staphylococcus aureus with IC₅₀ values of 1.5 and 0.5 μM, respectively. Compound 2 also displayed antifungal activity against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus, with IC₅₀ values of 5.4, 5.4, and 10.0 μM, respectively.