Assembly of an Injectable Noncytotoxic Peptide-Based Hydrogelator for Sustained Release of Drugs

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• 作者：Abhishek Baral ; Subhasish Roy ; Ashkan Dehsorkhi ; Ian W. Hamley ; Saswat Mohapatra ; Surajit Ghosh ; Arindam Banerjee
• 刊名：Langmuir
• 出版年：2014
• 出版时间：January 28, 2014
• 年：2014
• 卷：30
• 期：3
• 页码：929-936
• 全文大小：429K
• ISSN：1520-5827

文摘

A new synthetic tripeptide-based hydrogel has been discovered at physiological pH and temperature. This hydrogel has been thoroughly characterized using different techniques including field emission scanning electron microscopic (FE-SEM) and high-resolution transmission electron microscopic (HR-TEM) imaging, small- and wide-angle X-ray diffraction analyses, FT-IR, circular dichroism, and rheometric analyses. Moreover, this gel exhibits thixotropy and injectability. This hydrogel has been used for entrapment and sustained release of an antibiotic vancomycin and vitamin B₁₂ at physiological pH and temperature for about 2 days. Interestingly, MTT assay of these gelator molecules shows almost 100% cell viability of this peptide gelator, indicating its noncytotoxicity.