Biomedical Applications of Poisonous Plant Research

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• 作者：Lynn F. James ; Kip E. Panter ; William Gaffield ; and Russell J. Molyneux
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2004
• 出版时间：June 2, 2004
• 年：2004
• 卷：52
• 期：11
• 页码：3211 - 3230
• 全文大小：1600K
• 年卷期：v.52,no.11(June 2, 2004)
• ISSN：1520-5118

文摘

Research designed to isolate and identify the bioactive compounds responsible for the toxicity ofplants to livestock that graze them has been extremely successful. The knowledge gained has beenused to design management techniques to prevent economic losses, predict potential outbreaks ofpoisoning, and treat affected animals. The availability of these compounds in pure form has nowprovided scientists with tools to develop animal models for human diseases, study modes of actionat the molecular level, and apply such knowledge to the development of potential drug candidatesfor the treatment of a number of genetic and infectious conditions. These advances are illustrated byspecific examples of biomedical applications of the toxins of Veratrum californicum (western falsehellebore), Lupinus species (lupines), and Astragalus and Oxytropis species (locoweeds).Keywords: Poisonous plants; Veratrum; Lupinus; Astragalus; Oxytropis; cyclopamine; ammodendrine;anagyrine; swainsonine; cyclopia; teratogenicity; cleft palate; locoism; neurological defects; abortion;antimetastatic; antiviral