Batch Fermentation Networks Model for Optimal Synthesis, Design, and Operation

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• 作者：Gabriela Corsano ; Pí ; o A. Aguirre ; Oscar A. Iribarren ; and Jorge M. Montagna
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：2004
• 出版时间：July 21, 2004
• 年：2004
• 卷：43
• 期：15
• 页码：4211 - 4219
• 全文大小：128K
• 年卷期：v.43,no.15(July 21, 2004)
• ISSN：1520-5045

文摘

This paper addresses an integral optimization of fermentation processes. The behavior of thefermentors is described by a set of algebraic and differential equations written as finite-differenceequations in an equation-oriented environment. Unconventional constraints related to thenumber of batch items and connections among them, detailed kinetic models and operating costscorresponding to inoculum, and different available substrates are included in the model. Theoptimal number of units to be used in the process, their optimal operation policy (i.e., connectedin series or in parallel working out of phase), as well as the optimal volume and operation ofeach unit, are determined simultaneously. The model is formulated as a sequence of nonlinearprogramming (NLP) problems.