Tissue Engineering of Small Intestine-Current Status
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- 作者：Ashish Gupta ; Anupam Dixit ; Kevin M. Sales ; Marc C. Winslet ; Alexander M. Seifalian
- 刊名：Biomacromolecules
- 出版年：2006
- 出版时间：October 2006
- 年：2006
- 卷：7
- 期：10
- 页码：2701 - 2709
- 全文大小：579K
- 年卷期：v.7,no.10(October 2006)
- ISSN：1526-4602
文摘
Short bowel syndrome (SBS) has always posed a great threat to patients and has been one of the biggest challengesfor doctors due to its high morbidity and mortality. So far, parenteral nutrition (PN) and small bowel transplantationremain the only viable therapeutic options. However, sepsis and liver failure associated with PN and limitedavailability of the donor organs and high graft rejection rates associated with transplantation have limited theiruse to a nonpermanent solution. Clearly, there is a need for an alternative therapy whereby increasing the absorptivesurface area would help neonates and adults suffering from permanent intestinal failure. Techniques such assequential intestinal lengthening are being explored in animal models with little success. Attempts to engineersmall intestine since the late 1980s have achieved varying degrees of success in animal models with evolvingrefinements in biotechnology. The most encouraging results so far have been the generation of intestinal neomucosain the form of cysts when intestinal epithelial organoid units isolated from neonatal rats were seeded ontobiodegradable polymers before implantation in syngeneic adult rats' omentum. Although still experimental,continued attempts worldwide using cultured stem cells and improved polymer technology offer promise to providean off-the-shelf artificial intestine as a novel therapy for patients with SBS. This article reviews the current statusof progress in the field of small intestinal tissue engineering and addresses various types of cell sources andscaffold material having potential to be used in this field.