Inversion of the Relative Stability between Two Polymorphic Forms of (±) Modafinil under Dry High-Energy Milling: Comparisons with Results Obtained under Wet High-Energy Milling

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• 作者：Julie Linol ; Thomas Morelli ; Marie-Noë ; lle Petit ; Gé ; rard Coquerel
• 刊名：Crystal Growth & Design
• 出版年：2007
• 出版时间：September 2007
• 年：2007
• 卷：7
• 期：9
• 页码：1608 - 1611
• 全文大小：241K
• 年卷期：v.7,no.9(September 2007)
• ISSN：1528-7505

文摘

Among the seven different forms of (±) modafinil, form I is the most stable variety (at whatever the temperature,T), and form III is very close to form I in terms of lattice energy. Under high-energy milling (HEM), every modificationconverts into a defective form III. The inversion of "stability" between form I and form III is then evidenced when a high-poweredmechanical flux of energy is applied. When 3% mass/mass of water-a very poor solvent for this racemic compound-isintroduced in the vials, the same types of experiments lead to defective form I. This study tends to show that whatever the numberof polymorphic forms in the temperature, pressure (T, P) space, a single variety exists as a steady state for a given set of HEMparameters.