Enantioselective Hydroformylation of 1-Alkenes with Commercial Ph-BPE Ligand

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• 作者：Zhiyong Yu ; Meredith S. Eno ; Alexandra H. Annis ; James P. Morken
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：July 2, 2015
• 年：2015
• 卷：17
• 期：13
• 页码：3264-3267
• 全文大小：342K
• ISSN：1523-7052

文摘

A rhodium complex, in conjunction with commercially available Ph-BPE ligand, catalyzes the branch-selective asymmetric hydroformylation of 1-alkenes and rapidly generates 伪-chiral aldehydes. A wide range of terminal olefins including 1-dodecene were examined, and all delivered high enantioselectivity (up to 98:2 er) as well as good branch:linear ratios (up to 15:1).