Enantioselective Carbocycle Formation through Intramolecular Pd-Catalyzed Allyl鈥揂ryl Cross-Coupling

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• 作者：Christopher H. Schuster ; John R. Coombs ; Zachary A. Kasun ; James P. Morken
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：September 5, 2014
• 年：2014
• 卷：16
• 期：17
• 页码：4420-4423
• 全文大小：395K
• ISSN：1523-7052

文摘

Aryl electrophiles containing tethered allylboronate units undergo efficient intramolecular coupling in the presence of a chiral palladium catalyst to give enantioenriched carbocyclic products. The reaction is found to be quite general, affording 5, 6, and 7-membered carbocyclic products as single regioisomers and with moderate enantioselectivities. Examination of differential coupling partners points to rapid allyl-equilibration as a key stereodefining feature.