Nickel-Catalyzed Asymmetric Kumada Cross-Coupling of Symmetric Cyclic Sulfates
详细信息 查看全文
- 作者：Meredith S. Eno ; Alexander Lu ; James P. Morken
- 刊名：Journal of the American Chemical Society
- 出版年：2016
- 出版时间：June 29, 2016
- 年：2016
- 卷：138
- 期：25
- 页码：7824-7827
- 全文大小：438K
- 年卷期：0
- ISSN：1520-5126
文摘
Nickel-catalyzed enantioselective cross-couplings between symmetric cyclic sulfates and aromatic Grignard reagents are described. These reactions are effective with a broad range of substituted cyclic sulfates and deliver products with asymmetric tertiary carbon centers. Mechanistic experiments point to a stereoinvertive SN2-like oxidative addition of a nickel complex to the electrophilic substrate.