A Comparison of Commercial Microwave Reactors for Scale-Up within Process Chemistry

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• 作者：Jonathan D. Moseley ; Philip Lenden ; Mark Lockwood ; Katinka Ruda ; Jon-Paul Sherlock ; Anthony D. Thomson ; John P. Gilday
• 刊名：Organic Process Research & Development
• 出版年：2008
• 出版时间：January 2008
• 年：2008
• 卷：12
• 期：1
• 页码：30 - 40
• 全文大小：138K
• 年卷期：v.12,no.1(January 2008)
• ISSN：1520-586X

文摘

Seven commercially available microwave reactors designed for limited scale-up have been investigated using a highly reliable and robust reaction (the Newman−Kwart rearrangement). The use of a single reaction has enabled the comparison to be made across the range of different reactor types and scales. Overall, all reactors gave reliable scale-up from small scale, and performance equivalent to one another on large scale. A more detailed comparison between them is given in the concluding section.