Diverse Metabolic Profiles of a Streptomyces Strain Isolated from a Hyper-arid Environment
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- 作者：Mostafa E. Rateb ; Wael E. Houssen ; William T. A. Harrison ; Hai Deng ; Chinyere K. Okoro ; Juan A. Asenjo ; Barbara A. Andrews ; Alan T. Bull ; Michael Goodfellow ; Rainer Ebel ; Marcel Jaspars
- 刊名：Journal of Natural Products
- 出版年：2011
- 出版时间：September 23, 2011
- 年：2011
- 卷：74
- 期：9
- 页码：1965-1971
- 全文大小：858K
- 年卷期：v.74,no.9(September 23, 2011)
- ISSN：1520-6025
文摘
The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A鈥揅 (1鈥?b>3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5鈥?dihydrohygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1鈥?b>3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.