Asymmetric Catalysis Using Self-Assembled Chiral Bidentate P,P-Ligands
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- 作者：James M. Takacs ; D. Sahadeva Reddy ; Shin A. Moteki ; Di Wu ; and Hector Palencia
- 刊名：Journal of the American Chemical Society
- 出版年：2004
- 出版时间：April 14, 2004
- 年：2004
- 卷：126
- 期：14
- 页码：4494 - 4495
- 全文大小：91K
- 年卷期：v.126,no.14(April 14, 2004)
- ISSN：1520-5126
文摘
A strategy is described for modular catalyst development based upon metal-directed self-assembly of bifunctional subunits around a structural metal to form a heteroleptic complex in which a second set of ligating groups are now suitably disposed to bind a second metal to form a catalytic site. A library of chiral diphosphites was prepared via metal-directed self-assembly and used in a simple asymmetric allylic amination, giving enantiomeric excesses as high as 97%.