Intramolecular Friedel鈥揅rafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol

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• 作者：Hashim F. Motiwala ; Rakesh H. Vekariya ; Jeffrey Aub茅
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：November 6, 2015
• 年：2015
• 卷：17
• 期：21
• 页码：5484-5487
• 全文大小：371K
• ISSN：1523-7052

文摘

Simple dissolution of an arylalkyl acid chloride in 1,1,1,3,3,3-hexafluoro-2-propanol promotes an intramolecular Friedel鈥揅rafts acylation without additional catalysts or reagents. This reaction is operationally trivial in both execution and product isolation (only requiring concentration followed by purification) and accommodates a broad range of substrates. Preliminary studies that bear upon potential reaction mechanisms are reported.