Trifluoromethanesulfonyl Hypervalent Iodonium Ylide for Copper-Catalyzed Trifluoromethylthiolation of Enamines, Indoles, and 尾-Keto Esters
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- 作者：Yu-Dong Yang ; Ayaka Azuma ; Etsuko Tokunaga ; Mikio Yamasaki ; Motoo Shiro ; Norio Shibata
- 刊名：The Journal of the American Chemical Society
- 出版年：2013
- 出版时间：June 19, 2013
- 年：2013
- 卷：135
- 期：24
- 页码：8782-8785
- 全文大小：324K
- 年卷期：v.135,no.24(June 19, 2013)
- ISSN：1520-5126
文摘
A novel electrophilic-type trifluoromethylthiolation reagent, a trifluoromethanesulfonyl hypervalent iodonium ylide, was designed and reacted well with various nucleophiles to afford the desired CF3S-substituted products. In situ reduction of the trifluoromethanesulfonyl group to give the trifluoromethylthio group, which is the key step in this process, was realized in the presence of copper(I) chloride.