Core-like Particles of an Enveloped Animal Virus Can Self-Assemble Efficiently on Artificial Templates

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• 作者：Nancy L. Goicochea ; Mrinmoy De ; Vincent M. Rotello ; Suchetana Mukhopadhyay ; Bogdan Dragnea
• 刊名：Nano Letters
• 出版年：2007
• 出版时间：August 2007
• 年：2007
• 卷：7
• 期：8
• 页码：2281 - 2290
• 全文大小：680K
• 年卷期：v.7,no.8(August 2007)
• ISSN：1530-6992

文摘

Alphaviruses are animal viruses holding great promise for biomedical applications as drug delivery vectors, functional imaging probes, andnanoparticle delivery vesicles because of their efficient in vitro self-assembly properties. However, due to their complex structure, with aprotein capsid encapsulating the genome and an outer membrane composed of lipids and glycoproteins, the in-vitro self-assembly of virus-like particles, which have the functional virus coat but carry an artificial cargo, can be challenging. Fabrication of such alphavirus-like particlesis likely to require a two-step process: first, the assembly of a capsid structure around an artificial core, second the addition of the membranelayer. Here we report progress made on the first step: the efficient self-assembly of the alphavirus capsid around a functionalized nanoparticlecore.