Double Arylation of Allyl Alcohol via a One-Pot Heck Arylation鈥揑somerization鈥揂cylation Cascade

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• 作者：Paul Colbon ; Jiwu Ruan ; Mark Purdie ; Keith Mulholland ; Jianliang Xiao
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：October 21, 2011
• 年：2011
• 卷：13
• 期：20
• 页码：5456-5459
• 全文大小：783K
• 年卷期：v.13,no.20(October 21, 2011)
• ISSN：1523-7052

文摘

A one-pot, two-step catalytic protocol has been developed. A regioselective Heck coupling between aryl bromides and allyl alcohol leads to the generation of arylated allyl alcohols that in situ isomerize to give aldehydes, which then undergo an acylation reaction with a second aryl bromide. A variety of aryl bromides can be employed in both the initial Heck reaction and the acylation, providing easy access to a wide variety of substituted dihydrochalcones.