Accumulation, Transformation, and Elimination of Bis(tri-n-butyltin) Oxide in Red Sea Bream, Pagrus major, under Laboratory Conditions

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• 作者：Isao Yamamoto ; Kazuhiko Nishimura ; Takashi Suzuki ; Kayoko Takagi ; Hisashi Yamada ; Kazunari Kondo ; and Mitsunori Murayama
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：1997
• 出版时间：April 1997
• 年：1997
• 卷：45
• 期：4
• 页码：1437 - 1446
• 全文大小：194K
• 年卷期：v.45,no.4(April 1997)
• ISSN：1520-5118

文摘

Red sea bream (Pagrus major) were exposed tobis(tri-n-butyltin) oxide (TBTO), andaccumulation,transformation, and excretion of TBTO in the muscle, liver, gills, anddigestive tract were observed.Only two organotin compounds, tri-n-butyltin chloride(TBTC) and di-n-butyltin chloride (DBTC),were detected in the muscle, and TBTC accounted for more than 96% ofthe organotin compoundsat 8 weeks after TBTO treatment. In addition to these compounds,hydroxylated, carboxylated,and oxygenated compounds of TBTC or DBTC were also found in the liver,gills, and digestive tract.The metabolic pattern in the red sea bream liver was significantlydifferent from that in the liverof mammalian but similar to that in the gills and digestive tract andin general agreement withthat found in the natural marine environment, which was surveyed in anearlier work.Keywords: TBTO; bis(tri-n-butyltin) oxide; red sea bream;Pagrus major; fish; uptake; accumulation;metabolism; depuration; elimination; viscera; gas chromatography/heliumatmospheric pressuremicrowave-induced plasma/atomic emission detection system;GC/MIP/AED