Biologically Active Carbazole Alkaloids from Murraya koenigii
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- 作者：Russel S. Ramsewak ; Muraleedharan G. Nair ; Gale M. Strasburg ; David L. DeWitt ; and John L. Nitiss
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：1999
- 出版时间：February 1999
- 年：1999
- 卷：47
- 期：2
- 页码：444 - 447
- 全文大小：52K
- 年卷期：v.47,no.2(February 1999)
- ISSN：1520-5118
文摘
The bioassay guided fractionation of the acetone extract of the fresh leaves of Murraya koenigiiresulted in the isolation of three bioactive carbazole alkaloids, mahanimbine (1), murrayanol (2),and mahanine (3), as confirmed from their 1H and 13C NMR spectral data. Compound 2 showed anIC50 of 109 
g/mL against hPGHS-1 and an IC50 of 218 g/mL against hPGHS-2 in antiinflammatoryassays, while compound 1 displayed antioxidant activity at 33.1 g/mL. All three compounds weremosquitocidal and antimicrobial and exhibited topoisomerase I and II inhibition activities.Keywords: Murraya koenigii; carbazole alkaloid; mahanimbine; murrayanol; mahanine; mosquitocidal; antimicrobial; antiinflammatory; antioxidant
g/mL against hPGHS-1 and an IC50 of 218 g/mL against hPGHS-2 in antiinflammatoryassays, while compound 1 displayed antioxidant activity at 33.1 g/mL. All three compounds weremosquitocidal and antimicrobial and exhibited topoisomerase I and II inhibition activities.Keywords: Murraya koenigii; carbazole alkaloid; mahanimbine; murrayanol; mahanine; mosquitocidal; antimicrobial; antiinflammatory; antioxidant