Phytochemistry and Antifungal Properties of the Newly Discovered Tree Pleodendron costaricense
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- 作者：Virginie Treyvaud Amiguet ; Philippe Petit ; Chieu Anh Ta ; Ronaldo Nuñ ; ez ; Pablo Sá ; nchez-Vindas ; Luis Poveda Alvarez ; Myron L. Smith ; John Thor Arnason ; Tony Durst
- 刊名：Journal of Natural Products
- 出版年：2006
- 出版时间：July 2006
- 年：2006
- 卷：69
- 期：7
- 页码：1005 - 1009
- 全文大小：61K
- 年卷期：v.69,no.7(July 2006)
- ISSN：1520-6025
文摘
Gas chromatography analysis of the essential oils of leaves and bark collected from the newly discovered tree Pleodendroncostaricense identified 
-pinene, 
-pinene, -myrcene, -thujene, and -caryophyllene as their major constituents.Phytochemical analysis of P. costaricense parts led to the isolation and identification of 
-tocotrienol, -sitosterol, fourknown drimane-type sesquiterpenes, cinnamodial (1), cinnamosmolide (2), polygodial (3), and mukaadial (4), and twonew compounds, a drimane-type sesquiterpene, parritadial (5), and an eremophilane-type sesquiterpene, pleodendione(6). Antifungal assays with the two major compounds, 1 and 2, were carried out, and results showed a high activity of1 against Alternaria alternata (MIC = 3.9 
g/mL), Candida albicans azole-resistant strain D10, and Wangielladermatitides (MICs = 15.6 g/mL). Compound 2 showed less potent antifungal activities than 1 but was more effectiveagainst Candida albicans azole-resistant strain CN1A (MIC = 23.4 g/mL) and Pseudallescheria boydii (MIC = 78.1g/mL). A combination of the dialdehyde sesquiterpenes with dillapiol showed a synergistic antifungal effect with 1and an additive effect with 4 and 5.
-pinene, -pinene, -myrcene, -thujene, and -caryophyllene as their major constituents.Phytochemical analysis of P. costaricense parts led to the isolation and identification of -tocotrienol, -sitosterol, fourknown drimane-type sesquiterpenes, cinnamodial (1), cinnamosmolide (2), polygodial (3), and mukaadial (4), and twonew compounds, a drimane-type sesquiterpene, parritadial (5), and an eremophilane-type sesquiterpene, pleodendione(6). Antifungal assays with the two major compounds, 1 and 2, were carried out, and results showed a high activity of1 against Alternaria alternata (MIC = 3.9 g/mL), Candida albicans azole-resistant strain D10, and Wangielladermatitides (MICs = 15.6 g/mL). Compound 2 showed less potent antifungal activities than 1 but was more effectiveagainst Candida albicans azole-resistant strain CN1A (MIC = 23.4 g/mL) and Pseudallescheria boydii (MIC = 78.1g/mL). A combination of the dialdehyde sesquiterpenes with dillapiol showed a synergistic antifungal effect with 1and an additive effect with 4 and 5.