Hyalachelins A鈥揅, Unusual Siderophores Isolated from the Terrestrial Myxobacterium Hyalangium minutum

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• 作者：Suvd Nadmid ; Alberto Plaza ; Gianluigi Lauro ; Ronald Garcia ; Giuseppe Bifulco ; Rolf M眉ller
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：August 15, 2014
• 年：2014
• 卷：16
• 期：16
• 页码：4130-4133
• 全文大小：225K
• ISSN：1523-7052

文摘

Three new siderophores, termed hyalachelins A鈥揅 (1鈥?b>3), were isolated from the terrestrial myxobacterium Hyalangium minutum. Their structures were determined by 2D NMR and HR-MS/MS experiments, and their stereochemical configuration was established by a combination of NMR data, quantum mechanical calculations, and circular dichroism experiments. Hyalachelins are unusual catecholate-type siderophores that bear a 3,7,8-trihydroxy-1-oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid. Their iron chelating activities were evaluated in a CAS assay showing EC₅₀ values of 30 渭M.