Total Synthesis of (+)-Decarbamoylsaxitoxin and (+)-Gonyautoxin 3

详细信息    查看全文

• 作者：Osamu Iwamoto ; Kazuo Nagasawa
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：May 7, 2010
• 年：2010
• 卷：12
• 期：9
• 页码：2150-2153
• 全文大小：247K
• 年卷期：v.12,no.9(May 7, 2010)
• ISSN：1523-7052

文摘

Facile construction of the complex saxitoxin (STX) skeleton is carried out by using a novel, conformationally controlled, guanidine cyclization process that relies on the use of neighboring group participation. The utility of this methodology is verified by its employment in syntheses of both natural and unnatural STX derivatives.