Absolute Structure of Prunustatin A, a Novel GRP78 Molecular Chaperone Down-Regulator

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• 作者：Yukiko Umeda ; Kazuo Furihata ; Shohei Sakuda ; Hiromichi Nagasawa ; Ken Ishigami ; Hidenori Watanabe ; Miho Izumikawa ; Motoki Takagi ; Takayuki Doi ; Yoichi Nakao ; Kazuo Shin-ya
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：October 11, 2007
• 年：2007
• 卷：9
• 期：21
• 页码：4239 - 4242
• 全文大小：87K
• 年卷期：v.9,no.21(October 11, 2007)
• ISSN：1523-7052

文摘

In the course of our screening program for regulators of a molecular chaperone GRP78 expression, we isolated a novel inhibitor of GRP78expression, designated as prunustatin A, from Streptomyces violaceoniger 4521-SVS3. The planar structure of prunustatin A was determinedto be an oxidized type of the neoantimycin family. Its absolute stereochemistry was established to be 2R, 4S, 6S, 7R, 9S, and 29S by analyzingchemically degraded components obtained from the derivative of prunustatin A.