Neocomplanines A and B, a Complanine Family Isolated from the Marine Fireworm

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• 作者：Kazuhiko Nakamura ; Yu Tachikawa ; Osamu Ohno ; Makoto Kitamura ; Masami Suganuma ; Daisuke Uemura
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：March 26, 2010
• 年：2010
• 卷：73
• 期：3
• 页码：303-305
• 全文大小：141K
• 年卷期：v.73,no.3(March 26, 2010)
• ISSN：1520-6025

文摘

Two new members of the complanine family, neocomplanines A (2) and B (3), were isolated as minor components of the methanolic extract of the “marine fireworm” Eurythoe complanata. The structures of the neocomplanines were revealed spectroscopically to be a trimethylammonium unit with a saturated carbon chain. The planar structures of neocomplanines A and B were confirmed successfully through total syntheses that used epichlorohydrin as a starting material. The neocomplanines show inflammatory activity and also enhanced PKC activity in combination with TPA in the presence of Ca²⁺ in vitro; both are similar to the effects of complanine (1). The molecular mechanism of the effects of complanine-related compounds is discussed.