Enantioselective Oxidative Ring-Opening Reaction of Aziridines with α-Nitroesters Using Cinchona Alkaloid Amide/Nickel(II) Catalysts
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- 作者：Noriyuki Shiomi ; Keisuke Yamamoto ; Kazuma Nagasaki ; Tsubasa Hatanaka ; Yasuhiro Funahashi ; Shuichi Nakamura
- 刊名：Organic Letters
- 出版年：2017
- 出版时间：January 6, 2017
- 年：2017
- 卷：19
- 期：1
- 页码：74-77
- 全文大小：404K
- ISSN：1523-7052
文摘
The enantioselective oxidative ring-opening reaction of aziridines with α-nitroacetates has been developed. Good yields and enantioselectivity were observed for the reaction of various aziridines using a novel cinchona alkaloid amide/NiBr2 catalyst. Both enantiomers of products could be obtained by using pseudoenantiomeric chiral catalysts. This process offers an efficient route for the synthesis of α-aminoketones.