[Cu(OH)(TMEDA)]2Cl2-Catalyzed Regioselective 2-Arylation of 5-Substituted Tetrazoles with Boronic Acids under Mild Conditions

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• 作者：Takuya Onaka ; Hideaki Umemoto ; Yasuyoshi Miki ; Akira Nakamura ; Tomohiro Maegawa
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：July 18, 2014
• 年：2014
• 卷：79
• 期：14
• 页码：6703-6707
• 全文大小：273K
• ISSN：1520-6904

文摘

A mild and regioselective 2-arylation of 5-substituted tetrazoles is described. The reaction proceeds regioselectively with a variety of arylboronic acids in the presence of [Cu(OH)(TMEDA)]₂Cl₂ to afford 2,5-disubstituted tetrazoles. This is the first report of highly regioselective arylation of 5-alkyltetrazoles.