One-Pot Construction of 3,3鈥?Bisindolylmethanes through Bartoli Indole Synthesis

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• 作者：Takumi Abe ; Shuuhei Nakamura ; Reiko Yanada ; Tominari Choshi ; Satoshi Hibino ; Minoru Ishikura
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：July 19, 2013
• 年：2013
• 卷：15
• 期：14
• 页码：3622-3625
• 全文大小：300K
• 年卷期：v.15,no.14(July 19, 2013)
• ISSN：1523-7052

文摘

A one-pot approach to 3,3鈥?bisindolylmethane derivatives from nitrobenzene derivatives through the Bartoli indole synthesis was developed, in which the acid used to quench the reaction markedly affected its outcome. Quenching the reaction with concd HCl produced 3,3鈥?bisindolylmethane in contrast to the formation of 7-substituted indole by quenching with NH₄Cl.