Synthesis of Antioxidants for Prevention of Age-Related Macular Degeneration
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- 作者：Dharati Joshi ; James Field ; John Murphy ; Mohammed Abdelrahim ; Heike Sch枚nherr ; Janet R. Sparrow ; George Ellestad ; Koji Nakanishi ; Arie Zask
- 刊名：Journal of Natural Products
- 出版年：2013
- 出版时间：March 22, 2013
- 年：2013
- 卷：76
- 期：3
- 页码：450-454
- 全文大小：279K
- 年卷期：v.76,no.3(March 22, 2013)
- ISSN：1520-6025
文摘
Photooxidation of A2E may be involved in diseases of the macula, and antioxidants could serve as therapeutic agents for these diseases. Inhibitors of A2E photooxidation were prepared by Mannich reaction of the antioxidant quercetin. These compounds contain water-solubilizing amine groups, and several were more potent inhibitors of A2E photooxidation than quercetin.