Commercial Manufacturing of Propofol: Simplifying the Isolation Process and Control on Related Substances
详细信息 查看全文
- 作者：Chinmoy Pramanik ; Sandeep Kotharkar ; Pradip Patil ; Dinkar Gotrane ; Yogesh More ; Ajit Borhade ; Balaji Chaugule ; Tushar Khaladkar ; K. Neelakandan ; Ashok Chaudhari ; Mukund G. Kulkarni ; Narendra K. Tripathy ; Mukund K. Gurjar
- 刊名：Organic Process Research & Development
- 出版年：2014
- 出版时间：January 17, 2014
- 年：2014
- 卷：18
- 期：1
- 页码：152-156
- 全文大小：260K
- ISSN：1520-586X
文摘
A commercially viable manufacturing process for propofol (1) is described. The process avoids acid鈥揵ase neutralization events during isolation of intermediate, 2,6-di-isopropylbenzoic acid (3) and crude propofol, and thus simplifies the synthesis on industrial scale to a considerable extent. Syntheses of five impurities/related substances (USP and EP) are also described.