“Solvent-Less” Mechanochemical Approach to the Synthesis of Pyrimidine Derivatives

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• 作者：Tilak Raj ; Hemant Sharma ; Mayank ; Ajnesh Singh ; Thammarat AreeNavneet Kaur ; Narinder SinghDoo Ok Jang
• 刊名：ACS Sustainable Chemistry & Engineering
• 出版年：2017
• 出版时间：February 6, 2017
• 年：2017
• 卷：5
• 期：2
• 页码：1468-1475
• 全文大小：575K
• ISSN：2168-0485

文摘

Modified ZnO NPs were synthesized through a sol–gel route with an aromatic capping agent to provide a highly efficient catalyst, NS-5, for the one-pot multicomponent synthesis of various pyrimidine derivatives using a solvent-free ball milling technique. Greenness of the present method was evaluated by calculating an Ecoscale score and E-factor. Characteristics of the method include use of a recyclable catalyst, scale-up to a multigram scale, and ease of product isolation.