Microfiber-Directed Boundary Flow in Press-Fit Microdevices Fabricated from Self-Adhesive Hydrophobic Surfaces

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• 作者：Tom T. Huang ; David G. Taylor ; Miroslav Sedlak ; Nathan S. Mosier ; and Michael R. Ladisch
• 刊名：Analytical Chemistry
• 出版年：2005
• 出版时间：June 1, 2005
• 年：2005
• 卷：77
• 期：11
• 页码：3671 - 3675
• 全文大小：330K
• 年卷期：v.77,no.11(June 1, 2005)
• ISSN：1520-6882

文摘

We report a rapid microfluidic device construction technique which does not employ lithography or stampingmethods. Device assembly physically combines a siliconwafer, an elastomer (poly(dimethylsiloxane) (PDMS)), andmicrofibers to form patterns of hydrophobic channels,wells, elbows, or orifices that direct fluid flow intocontrolled boundary layers. Tweezers are used to placeglass microfibers in a defined pattern onto an elastomeric(PDMS) hydrophobic film. The film is then manuallypressed onto a hydrophobic silicon wafer, causing it toadhere to the silicon wafer and form a liquid-tight sealaround the fibers. Completed in 15 min, the techniqueresults in an operable microdevice with micrometer-scalefeatures of nanoliter volume. Microfiber-directed boundary flow is achieved by use of the surface wetting properties of the hydrophilic glass fiber and the hydrophobicityof surrounding surfaces. The simplicity of this techniqueallows quick prototyping of microfluidic components, aswell as complete biosensor systems, such as we describefor the detection of pathogenic bacteria.