Localized Delivery of Dexamethasone from Electrospun Fibers Reduces the Foreign Body Response

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• 作者：Nathaniel M. Vacanti ; Hao Cheng ; Paulina S. Hill ; Jo茫o D.T. Guerreiro ; Tram T. Dang ; Minglin Ma ; Shan茅e Watson ; Nathaniel S. Hwang ; Robert Langer ; Daniel G. Anderson
• 刊名：Biomacromolecules
• 出版年：2012
• 出版时间：October 8, 2012
• 年：2012
• 卷：13
• 期：10
• 页码：3031-3038
• 全文大小：545K
• 年卷期：v.13,no.10(October 8, 2012)
• ISSN：1526-4602

文摘

Synthetic scaffolds are crucial to applications in regenerative medicine; however, the foreign body response can impede regeneration and may lead to failure of the implant. Herein we report the development of a tissue engineering scaffold that allows attachment and proliferation of regenerating cells while reducing the foreign body response by localized delivery of an anti-inflammatory agent. Electrospun fibers composed of poly(l-lactic) acid (PLLA) and poly(蔚-caprolactone) (PCL) were prepared with and without the steroid anti-inflammatory drug, dexamethasone. Analysis of subcutaneous implants demonstrated that the PLLA fibers encapsulating dexamethasone evoked a less severe inflammatory response than the other fibers examined. They also displayed a controlled release of dexamethasone over a period of time conducive to tissue regeneration and allowed human mesenchymal stem cells to adhere to and proliferate on them in vitro. These observations demonstrate their potential as a building block for tissue engineering scaffolds.