Synthesis of the C22–C40 Domain of the Azaspiracids
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- 作者：Zhigao Zhang ; Yong Chen ; Daniel Adu-Ampratwum ; Antony Akura Okumu ; Nathaniel T. Kenton ; Craig J. Forsyth
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：April 15, 2016
- 年：2016
- 卷：18
- 期：8
- 页码：1824-1827
- 全文大小：407K
- 年卷期：0
- ISSN：1523-7052
文摘
An efficient synthesis of the C22–C40 domain of the azaspiracids is described. The synthetic route features a Nozaki–Hiyama–Kishi (NHK) coupling and chelation controlled Mukaiyama aldol reaction to access an acyclic intermediate and a double-intramolecular-hetero-Michael addition (DIHMA) to provide the FG-ring system bridged ketal.