Direct FeX3-Based Stereocontrolled Access to (Z)-3-Alkenyl-oxindoles from Allenols

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• 作者：Benito Alcaide ; Pedro Almendros ; Amparo Luna ; Natividad Prieto
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：December 21, 2012
• 年：2012
• 卷：77
• 期：24
• 页码：11388-11392
• 全文大小：238K
• 年卷期：v.77,no.24(December 21, 2012)
• ISSN：1520-6904

文摘

Iron trihalides (FeCl₃ and FeBr₃) smoothly promote the halogenation/rearrangement of 2-indolinone-tethered allenols to efficiently afford 3-halodienyl-oxindoles with good yield and total selectivity. Also, 2-halo-1,3-dienes are synthetically interesting building blocks for the preparation of functionalized 3-alkenyl-oxindoles through a Suzuki鈥揗iyaura reaction.