γ-Lactones and ent-Eudesmane Sesquiterpenes from the Endophytic Fungus Eutypella sp. BCC 13199

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• 作者：Masahiko Isaka ; Somporn Palasarn ; Sanisa Lapanun ; Rungtiwa Chanthaket ; Nattawut Boonyuen ; Saisamorn Lumyong
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：September 25, 2009
• 年：2009
• 卷：72
• 期：9
• 页码：1720-1722
• 全文大小：117K
• 年卷期：v.72,no.9(September 25, 2009)
• ISSN：1520-6025

文摘

Two new γ-lactones, eutypellins A (1) and B (2), and two ent-eudesmane sesquiterpenes, ent-4(15)-eudesmen-11-ol-1-one (3) and ent-4(15)-eudesmen-1α,11-diol (4), together with three known pimarane diterpenes, diaporthein B, scopararane A, and libertellenone C, were isolated from the endophytic fungus Eutypella sp. BCC 13199. The structures of these compounds were elucidated by interpretation of spectroscopic data. The absolute configuration of 4 was confirmed by application of the modified Mosher’s method. Eutypellin A (1) and sesquiterpene 3 exhibited weak cytotoxic activities.