14-Membered Macrocyclic Ring-Derived Toolbox: The Identification of Small Molecule Inhibitors of Angiogenesis and Early Embryo Development in Zebrafish Assay

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• 作者：Madhu Aeluri ; Chinmoy Pramanik ; Lakshindra Chetia ; Naveen Kumar Mallurwar ; Sridhar Balasubramanian ; Gayathri Chandrasekar ; Satish Srinivas Kitambi ; Prabhat Arya
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：February 1, 2013
• 年：2013
• 卷：15
• 期：3
• 页码：436-439
• 全文大小：313K
• 年卷期：v.15,no.3(February 1, 2013)
• ISSN：1523-7052

文摘

A highly practical and modular synthesis to obtain a diverse 14-membered ring-based macrocyclic toolbox is achieved. These compounds were further tested in zebrafish assays related to early embryonic development, angiogenesis, and neurogenesis, respectively. 1.4c was identified as an antiangiogenesis agent.